Fetal to Adult Stem Cell Transition: Knocking Sox17 off
نویسندگان
چکیده
What controls the inherent differences between fetal and adult hematopoietic stem cells (HSCs)? In this issue of Cell, Kim et al. (2007) demonstrate in mice that the endodermal transcription factor Sox17 is required for the maintenance of fetal and neonatal but not adult HSCs.
منابع مشابه
Sox17 Dependence Distinguishes the Transcriptional Regulation of Fetal from Adult Hematopoietic Stem Cells
Fetal stem cells differ phenotypically and functionally from adult stem cells in diverse tissues. However, little is known about how these differences are regulated. To address this we compared the gene expression profiles of fetal versus adult hematopoietic stem cells (HSCs) and discovered that the Sox17 transcriptional regulator is specifically expressed in fetal and neonatal but not adult HS...
متن کاملSox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors.
A key question concerns the mechanisms that determine temporal identity in stem cells. Fetal hematopoietic stem cells (HSCs) differ from adult HSCs in terms of gene expression profile, surface marker expression, differentiation, and self-renewal capacity. We previously showed that the transcription factor SOX17 is expressed by fetal, but not adult, HSCs and is required for the maintenance of fe...
متن کاملDifferential Expression Pattern of the Human Endoderm-Specific Transcription Factor Sox17 in Various Tissues and Cells
BACKGROUND Sox17 is a member of the Sry-related high mobility group (HMG) of transcription factors that is necessary for endodermal formation and liver development in multiple species. Sox17 gene expression is required for formation of definitive endoderm that gives rise to various tissues. OBJECTIVE To examine the expression of Sox17 in various human tissues and cells. METHODS Semiquantita...
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Examination of human fetal pancreatic endocrine cell development can provide further insight in, defining the developmental patterns of endocrine cells and identifying β-cell progenitors. In this study we performed a comprehensive immunohistochemical analysis of human fetal pancreatic sections aged from 7.7 to 38 weeks post conception (wpc), as well as 10 weeks post natal (wpn), and adult secti...
متن کاملSox17 Promotes Cell Cycle Progression and Inhibits TGF-β/Smad3 Signaling to Initiate Progenitor Cell Behavior in the Respiratory Epithelium
The Sry-related high mobility group box transcription factor Sox17 is required for diverse developmental processes including endoderm formation, vascular development, and fetal hematopoietic stem cell maintenance. Expression of Sox17 in mature respiratory epithelial cells causes proliferation and lineage respecification, suggesting that Sox17 can alter adult lung progenitor cell fate. In this p...
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ورودعنوان ژورنال:
- Cell
دوره 130 شماره
صفحات -
تاریخ انتشار 2007